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1

The Lilly Prize Lecture 1996 ‘Keep on taking the tablets’: pharmacological adaptation during long-term drug therapy

D. G. Grahame-Smith

Journal:

British Journal of Clinical Pharmacology

Year:

1997

Language:

english

File:

PDF, 744 KB

english, 1997

2

How will knowledge of the human genome affect drug therapy?

Journal:

British Journal of Clinical Pharmacology

Year:

1999

Language:

english

File:

PDF, 70 KB

english, 1999

3

The effect of lithium on 5-HT-mediated neuroendocrine responses and platelet 5-HT receptors

P. W. Glue, P. J. Cowen, D. J. Nutt, T. Kolakowska, D. G. Grahame-Smith

Journal:

Psychopharmacology

Year:

1986

Language:

english

File:

PDF, 492 KB

english, 1986

4

The relationship of Ara-C metabolism in vitro to therapeutic response in acute myeloid leukaemia

Adrian L. Harris, David G. Grahame-Smith

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1982

Language:

english

File:

PDF, 505 KB

english, 1982

5

Enhanced 5-hydroxytryptamine-mediated behavioural responses in rats following repeated electroconvulsive shock: Relevance to the mechanism of the antidepressive effect of electroconvulsive therapy

D. W. Costain, A. R. Green, D. G. Grahame-Smith

Journal:

Psychopharmacology

Year:

1979

Language:

english

File:

PDF, 343 KB

english, 1979

6

Single and repeated administration of neuroleptic drugs to rats: Effects on striatal dopamine-sensitive adenylate cyclase and locomotor activity produced by tranylcypromine andL-tryptophan orL-dopa

D. J. Heal, A. R. Green, D. J. Boullin, D. G. Grahame-Smith

Journal:

Psychopharmacology

Year:

1976

Language:

english

File:

PDF, 1.14 MB

english, 1976

7

Neuroleptic drugs block both the hyperactivity and the increase in caudate nucleus cyclic AMP concentration produced by the administration of tranylcypromine andl-dopa to rats

D. J. Heal, A. R. Green, M. R. Bloomfield, D. G. Grahame-Smith

Journal:

Psychopharmacology

Year:

1978

Language:

english

File:

PDF, 478 KB

english, 1978

8

The effect of repeated electroconvulsive shocks on growth hormone secretion and growth hormone responses to clonidine in the intact rat

J. A. Steiner, G. Evans, D. G. Grahame-Smith

Journal:

Psychopharmacology

Year:

1982

Language:

english

File:

PDF, 289 KB

english, 1982

9

Repeated administration of subconvulsant doses of GABA antagonist drugs

David J. Nutt, Philip J. Cowen, Celia C. Batts, David G. Grahame-Smith, A. Richard Green

Journal:

Psychopharmacology

Year:

1982

Language:

english

File:

PDF, 377 KB

english, 1982

10

The effect of repeated electroconvulsive shock on corticosterone responses to centrally acting pharmacological stimuli in the male rat

J. A. Steiner, D. G. Grahame-Smith

Journal:

Psychopharmacology

Year:

1980

Language:

english

File:

PDF, 646 KB

english, 1980

11

Central pharmacological control of corticosterone secretion in the intact rat. demonstration of cholinergic and serotoninergic facilitatory and α-adrenergic inhibitory mechanisms

J. A. Steiner, D. G. Grahame-Smith

Journal:

Psychopharmacology

Year:

1980

Language:

english

File:

PDF, 493 KB

english, 1980

12

Further observations on the effect of repeated electroconvulsive shock on the behavioural resposes of rats produced by increases in the functional activity of brain 5-hydroxytryptamine and dopamine

A. R. Green, D. J. Heal, D. G. Grahame-Smith

Journal:

Psychopharmacology

Year:

1977

Language:

english

File:

PDF, 553 KB

english, 1977

13

Preclinical toxicological testing and safeguards in clinical trials

D. G. Grahame-Smith

Journal:

European Journal of Clinical Pharmacology

Year:

1982

Language:

english

File:

PDF, 734 KB

english, 1982

14

Techniques for studying the pharmacodynamic effects of cardiac glycosides on patients' own erythrocytes during glycoside therapy

J. K. Aronson, A. R. Ford, D. G. Grahame-Smith

Journal:

Journal of Molecular Medicine

Year:

1981

Language:

english

File:

PDF, 977 KB

english, 1981

15

Human platelet 5-hydroxytryptamine receptors: Binding of [3H]-lysergic acid diethylamide (LSD). Effects of chronic neuroleptic and antidepressant drug administration

D. G. Grahame-Smith, D. P. Geaney, M. Schachter, J. M. Elliott

Journal:

Cellular and Molecular Life Sciences

Year:

1988

Language:

english

File:

PDF, 551 KB

english, 1988

16

The effects of gepirone on neuroendocrine function and temperature in humans

I. M. Anderson, P. J. Cowen, D. G. Grahame-Smith

Journal:

Psychopharmacology

Year:

1990

Language:

english

File:

PDF, 758 KB

english, 1990

17

Effects of carbamazepine on 5-hydroxytryptamine function in rodents

M. Elphick, S. M. P. Anderson, K. F. Hallis, D. G. Grahame-Smith

Journal:

Psychopharmacology

Year:

1990

Language:

english

File:

PDF, 685 KB

english, 1990

18

Repeated ECS enhances dopamine D-1 but not D-2 agonist-induced behavioural responses in rats

T. Sharp, J. Kingston, D. G. Grahame-Smith

Journal:

Psychopharmacology

Year:

1990

Language:

english

File:

PDF, 732 KB

english, 1990

19

Effects of the 5-HT1Apartial agonists gepirone, ipsapirone and buspirone on local cerebral glucose utilization in the conscious rat

P. M. Grasby, T. Sharp, T. Allen, P. A. T. Kelly, D. G. Grahame-Smith

Journal:

Psychopharmacology

Year:

1992

Language:

english

File:

PDF, 695 KB

english, 1992

20

Effects of chronic lithium, amitriptyline, and electroconvulsive shock, on calcium channel binding in a rat brain homogenate

Peter H. Silverstone, David G. Grahame-Smith

Journal:

Psychopharmacology

Year:

1991

Language:

english

File:

PDF, 275 KB

english, 1991

21

Adverse drug reactions in a hospital general medical unit meriting notification to the Committee on Safety of Medicines

C. C. SMITH, P. M. BENNETT, H. M. PEARCE, P. I. HARRISON, D. J. M. REYNOLDS, J. K. ARONSON, D. G. GRAHAME-SMITH

Journal:

British Journal of Clinical Pharmacology

Year:

1996

Language:

english

File:

PDF, 189 KB

english, 1996

22

TRYPTOPHAN TRANSPORT ACROSS THE SYNAPTOSOMAL MEMBRANE

D. G. Grahame-Smith, A. G. Parfitt

Journal:

Journal of Neurochemistry

Year:

1970

Language:

english

File:

PDF, 892 KB

english, 1970

23

STUDIES IN VIVO ON THE RELATIONSHIP BETWEEN BRAIN TRYPTOPHAN, BRAIN 5-HT SYNTHESIS AND HYPERACTIVITY IN RATS TREATED WITH A MONOAMINE OXIDASE INHIBITOR AND L-TRYPTOPHAN

D. G. Grahame-Smith

Journal:

Journal of Neurochemistry

Year:

1971

Language:

english

File:

PDF, 722 KB

english, 1971

24

Effect of Lithium and of Other Drugs Used in the Treatment of Manic Illness on the Cation-Transporting Properties of Na+, K+-ATPase in Mouse Brain Synaptosomes

A. J. Wood, M. Elphick, D. G. Grahame-Smith

Journal:

Journal of Neurochemistry

Year:

1989

Language:

english

File:

PDF, 900 KB

english, 1989

25

In Vivo Measurement of Extracellular 5-Hydroxytryptamine in Hippocampus of the Anaesthetized Rat Using Microdialysis: Changes in Relation to 5-Hydroxytryptaminergic Neuronal Activity

Trevor Sharp, Steven R. Bramwell, David Clark, David G. Grahame-Smith

Journal:

Journal of Neurochemistry

Year:

1989

Language:

english

File:

PDF, 735 KB

english, 1989

26

A COMPARISON OF α2-ADRENORECEPTOR BINDING CHARACTERISTICS OF INTACT HUMAN PLATELETS IDENTIFIED BY [3H]-YOHIMBINE AND [3H]-DIHYDROERGOCRYPTINE

N. A. BOON, J. M. ELLIOTT, D. G. GRAHAME-SMITH, T. St. JOHN-GREEN, K. STUMP

Journal:

Autonomic and Autacoid Pharmacology

Year:

1983

Language:

english

File:

PDF, 574 KB

english, 1983

27

Unchanged Rate of Brain Serotonin Synthesis during Chronic Morphine Treatment and Failure of Parachlorophenylalanine to attenuate Withdrawal Syndrome in Mice

MARSHALL, IAN, GRAHAME-SMITH, D. G.

Journal:

Year:

1970

File:

PDF, 312 KB

1970

28

Inhibition of adenyl cyclase by an exotoxin of Bacillus thuringiensis

GRAHAME-SMITH, D. G., ISAAC, P., HEAL, D. J., BOND, R. P. M.

Journal:

Year:

1975

File:

PDF, 352 KB

1975

29

Effects of drugs on the processes regulating the functional activity of brain 5-hydroxytryptamine

Richard Green, A., Grahame-Smith, David G.

Journal:

Year:

1976

File:

PDF, 639 KB

1976

30

(−)-Propranolol inhibits the behavioural responses of rats to increased 5-hydroxytryptamine in the central nervous system

GREEN, A. R., GRAHAME-SMITH, D. G.

Journal:

Year:

1976

File:

PDF, 351 KB

1976

31

Investment in UK universities

GRAHAME-SMITH, D. G.

Journal:

Year:

1990

File:

PDF, 124 KB

1990

32

Cost of brain disorders

Bloom, F. E., Cowey, A., Faull, R. L. M., Grahame-Smith, D. G., Gray, J. A., Hökfelt, T., Iversen, L. L., Llinas, R. R., Marsden, C. D., Purpura, D. P.

Journal:

Year:

1992

File:

PDF, 145 KB

1992

33

Workshop report: Academic pursuits in clinical pharmacology. Research emphasis

Mitchell, Jerry R, Grahame-Smith, David G

Journal:

Clinical Pharmacology & Therapeutics

Year:

1986

Language:

english

File:

PDF, 284 KB

english, 1986

34

5-HT2AReceptor Activation Leads to Increased BDNF mRNA expression in C6 glioma cells

Robert Meller, Joseph M. Babity, David G. Grahame-Smith

Journal:

NeuroMolecular Medicine

Year:

2002

Language:

english

File:

PDF, 153 KB

english, 2002

35

Cytosine arabinoside triphosphate production in human leukaemic myeloblasts: Interactions with deoxycytidine

Adrian L. Harris, David G. Grahame-Smith

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1981

Language:

english

File:

PDF, 591 KB

english, 1981

36

Penetration of C14-labelled rifampicin into primate peripheral nerve

A. C. McDougall, J. A. Rose, D. G. Grahame-Smith

Journal:

Cellular and Molecular Life Sciences

Year:

1975

Language:

english

File:

PDF, 239 KB

english, 1975

37

5-HT1A and 5-HT2 receptors differentially regulate the excitability of 5-HT-containing neurones of the guinea pig dorsal raphe nucleus in vitro

Rebecca M. Craven, David G. Grahame-Smith, Nigel R. Newberry

Journal:

Year:

2001

Language:

english

File:

PDF, 366 KB

english, 2001

38

Variation in Sensitivity of DNA Synthesis to Ara-C in Acute Myeloid Leukaemia

Adrian L. Harris, D. G. Grahame-Smith

Journal:

British Journal of Haematology

Year:

1980

Language:

english

File:

PDF, 474 KB

english, 1980

39

Action of adenosine receptor antagonists on hypoxia-induced effects in the rat hippocampus in vitro

M.D.R. Croning, T.S.C. Zetterstróm, D.G. Grahame-Smith, N.R. Newberry

Journal:

British Journal of Pharmacology

Year:

1995

Language:

english

File:

PDF, 1.62 MB

english, 1995

40

Pharmacological blockade of carcinoid flushing provoked by catecholamines and alcohol

A.R. Adamson, D.G. Grahame-Smith, W.S. Peart, M. Starr

Journal:

American Heart Journal

Year:

1971

Language:

english

File:

PDF, 224 KB

english, 1971

41

The carcinoid syndrome

David G. Grahame-Smith

Journal:

The American Journal of Cardiology

Year:

1968

Language:

english

File:

PDF, 1.05 MB

english, 1968

42

The effects of a low extracellular concentration of potassium on the activity and numbers of Na+/K+ pumps in an EB-virus transformed human lymphocyte cell line

D.G. Kennedy, J.K. Aronson, J.G. Bloomfield, D.G. Grahame-Smith

Journal:

Biochimica et Biophysica Acta (BBA) - Biomembranes

Year:

1990

Language:

english

File:

PDF, 654 KB

english, 1990

43

Cisplatin-evoked induction of c-fos protein in the brainstem of the ferret: the effect of cervical vagotomy and the anti-emetic 5-HT3 receptor antagonist granisetron (BRL 43694)

D.J.M. Reynolds, N.A. Barber, D.G. Grahame-Smith, R.A. Leslie

Journal:

Year:

1991

Language:

english

File:

PDF, 1.76 MB

english, 1991

44

Oestrogen and progesterone change the binding characteristics of α-adrenergic and serotonin receptors on rabbit platelets

J.Martin Elliot, John R. Peters, Davis G. Grahame-Smith

Journal:

European Journal of Pharmacology

Year:

1980

Language:

english

File:

PDF, 726 KB

english, 1980

45

Human platelet 5HT receptors: Characterisation and functional association

John R. Peters, David G. Grahame-Smith

Journal:

European Journal of Pharmacology

Year:

1980

Language:

english

File:

PDF, 803 KB

english, 1980

46

Characterisation of [3H]lysergic acid diethylamide binding to a 5-hydroxytryptamine receptor on human platelet membranes

David P. Geaney, Michael Schächter, J.Martin Elliot, David G. Grahame-Smith

Journal:

European Journal of Pharmacology

Year:

1984

Language:

english

File:

PDF, 443 KB

english, 1984

47

GABAB receptor activation inhibits 5-hydroxytryptamine-stimulated inositol phospholipid turnover in mouse cerebral cortex

Philip P. Godfrey, David G. Grahame-Smith, Julian A. Gray

Journal:

European Journal of Pharmacology

Year:

1988

Language:

english

File:

PDF, 303 KB

english, 1988

48

Further investigation of the in vivo pharmacological properties of the putative 5-HT1A antagonist, BMY 7378

Trevor Sharp, Lisa I. Backus, Stephen Hjorth, Steven R. Bramwell, David G. Grahame-Smith

Journal:

European Journal of Pharmacology

Year:

1990

Language:

english

File:

PDF, 902 KB

english, 1990

49

Localization of 5-HT3 receptor binding sites in human dorsal vagal complex

D.John M. Reynolds, Ronald A. Leslie, David G. Grahame-Smith, Jennifer M. Harvey

Journal:

European Journal of Pharmacology

Year:

1989

Language:

english

File:

PDF, 311 KB

english, 1989

50

Effect of calcium channel antagonists on electrically-evoked release of 5-HT in rat hippocampus in vivo as studied by microdialysis

T. Sharp, S. Bramwell, D.G. Grahame-Smith

Journal:

European Journal of Pharmacology

Year:

1990

Language:

english

File:

PDF, 117 KB

english, 1990

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